Gualco Gabriela, Weiss Lawrence M, Bacchi Carlos E
Consultoria em Patologia, Botucatu, Sao Paulo, Brazil.
Appl Immunohistochem Mol Morphol. 2010 Jul;18(4):301-10. doi: 10.1097/PAI.0b013e3181cf1126.
MUM1/IRF4 protein is a member of the interferon regulatory factor (IRF) family of transcriptional factors initially described as downstream regulators of interferon signaling. The quantity of this factor varies within the hematopoietic system in a lineage and stage-specific way. It is considered to be a key regulator of several steps in lymphoid, myeloid, and dendritic cell differentiation and maturation. MUM1/IRF4 expression is observed in many lymphoid and myeloid malignancies, and may be a promising target for the treatment of some of these neoplasms. We reviewed the literature on MUM1/IRF4, with emphasis on the pathologic aspects of this marker in reactive and malignant hematologic and nonhematologic conditions.
MUM1/IRF4蛋白是干扰素调节因子（IRF）转录因子家族的成员，最初被描述为干扰素信号传导的下游调节因子。该因子的数量在造血系统中以谱系和阶段特异性的方式变化。它被认为是淋巴细胞、髓细胞和树突状细胞分化及成熟过程中多个步骤的关键调节因子。在许多淋巴和髓系恶性肿瘤中可观察到MUM1/IRF4的表达，它可能是治疗其中一些肿瘤的有前景的靶点。我们回顾了关于MUM1/IRF4的文献，重点关注该标志物在反应性和恶性血液及非血液疾病中的病理学方面。
