Dwojak Ewa, Mroczek Magdalena, Dworacki Grzegorz, Dobosz Paula, Ślubowska Antonina, Stępień Maria, Borowczyk Martyna, Filipczyńska Izabela, Tomaszewska Agata, Ałtyn Rafał, Chowaniec Hanna
Department of Pathomorphology and Clinical Immunology, Poznan University of Medical Sciences, 60-355 Poznan, Poland.
Department of Pathomorphology, Poznan University Hospital, 60-355 Poznan, Poland.
Int J Mol Sci. 2024 Dec 5;25(23):13083. doi: 10.3390/ijms252313083.
There is an interplay between plasma cells, endometritis, and infertility, particularly in the context of in vitro fertilization (IVF) failure. This narrative literature review explains the pathophysiology of endometritis, detailing the involvement of various immune cells, cytokines, and chemokines in the regulation of inflammatory responses within the uterine endometrium. Here, we discuss the physiological role of plasma cells in immunity and their detection as markers of chronic endometritis, a disease associated with reproductive disorders. Our study also highlights the importance of CD138 immunohistochemical staining in the diagnosis of chronic endometritis, emphasizing the presence of plasma cells in endometrial tissue and its association with infertility and recurrent implantation failure. Of particular interest are the proposed diagnostic criteria for chronic endometritis based on the presence of plasma cells and studies that suggest a threshold for diagnosing this condition. We highlight the importance of examining the regenerative potential of endometrial stem cells in the treatment of infertility related to endometrial disorders.
浆细胞、子宫内膜炎和不孕症之间存在相互作用，尤其是在体外受精（IVF）失败的情况下。这篇叙述性文献综述解释了子宫内膜炎的病理生理学，详细阐述了各种免疫细胞、细胞因子和趋化因子在调节子宫内膜内炎症反应中的作用。在此，我们讨论浆细胞在免疫中的生理作用及其作为慢性子宫内膜炎标志物的检测，慢性子宫内膜炎是一种与生殖障碍相关的疾病。我们的研究还强调了CD138免疫组织化学染色在慢性子宫内膜炎诊断中的重要性，强调子宫内膜组织中浆细胞的存在及其与不孕症和反复种植失败的关联。特别值得关注的是基于浆细胞存在的慢性子宫内膜炎诊断标准以及表明该疾病诊断阈值的研究。我们强调了检查子宫内膜干细胞在治疗与子宫内膜疾病相关不孕症方面的再生潜力的重要性。
