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本文引用的文献

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Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia.接受伊马替尼治疗的慢性髓性白血病患者的五年随访
N Engl J Med. 2006 Dec 7;355(23):2408-17. doi: 10.1056/NEJMoa062867.
2
Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and recommendations for harmonizing current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results.监测接受酪氨酸激酶抑制剂治疗的慢性粒细胞白血病患者：关于统一当前检测BCR-ABL转录本和激酶结构域突变方法以及结果表达的综述与建议。
Blood. 2006 Jul 1;108(1):28-37. doi: 10.1182/blood-2006-01-0092. Epub 2006 Mar 7.
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Clinical and epidemiologic burden of chronic myelogenous leukemia.慢性粒细胞白血病的临床和流行病学负担
Expert Rev Anticancer Ther. 2004 Feb;4(1):85-96. doi: 10.1586/14737140.4.1.85.
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Chronic myeloid leukemia--advances in biology and new approaches to treatment.慢性髓性白血病——生物学进展与新的治疗方法
N Engl J Med. 2003 Oct 9;349(15):1451-64. doi: 10.1056/NEJMra020777.
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Chromosome studies in human leukemia. II. Chronic granulocytic leukemia.人类白血病的染色体研究。II. 慢性粒细胞白血病。
J Natl Cancer Inst. 1961 Nov;27:1013-35.
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Leukemia- and lymphoma-associated genetic aberrations in healthy individuals.健康个体中与白血病和淋巴瘤相关的基因畸变
Ann Hematol. 2002 Feb;81(2):64-75. doi: 10.1007/s00277-002-0427-x. Epub 2002 Jan 30.
7
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia.一种BCR-ABL酪氨酸激酶特异性抑制剂在慢性髓性白血病中的疗效与安全性
N Engl J Med. 2001 Apr 5;344(14):1031-7. doi: 10.1056/NEJM200104053441401.
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Chronic myeloid leukemia.慢性髓系白血病
N Engl J Med. 1999 Apr 29;340(17):1330-40. doi: 10.1056/NEJM199904293401706.
9
Simple and reliably sensitive diagnosis and monitoring of Philadelphia chromosome-positive cells in chronic myeloid leukemia by interphase fluorescence in situ hybridization of peripheral blood cells.通过外周血细胞间期荧光原位杂交技术对慢性髓性白血病中费城染色体阳性细胞进行简单且可靠灵敏的诊断与监测。
Leukemia. 1999 Apr;13(4):542-52. doi: 10.1038/sj.leu.2401383.
10
The presence of typical and atypical BCR-ABL fusion genes in leukocytes of normal individuals: biologic significance and implications for the assessment of minimal residual disease.正常个体白细胞中典型和非典型BCR-ABL融合基因的存在：生物学意义及对微小残留病评估的影响
Blood. 1998 Nov 1;92(9):3362-7.

无症状患者中BCR-ABL阳性细胞的检测：一例报告及文献综述

Detection of BCR-ABL Positive Cells in an Asymptomatic Patient: A Case Report and Literature Review.

作者信息

Bayraktar Soley, Goodman Mark

机构信息

Slyvester Comprehensive Cancer Center, 1475 NW Ave, Suite 3300, Miami, FL 33136, USA.

出版信息

Case Rep Med. 2010;2010:939706. doi: 10.1155/2010/939706. Epub 2010 Feb 18.

DOI:10.1155/2010/939706
PMID:20182545
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2825650/
Abstract

We report a case of an asymptomatic 39-year-old male who was incidentally found to have a white blood cell count of 15 000/mm(3) associated with a positive BCR-ABL/t(9;22)(q34;q11) chromosomal translocation detected in 51/300 of cells by FISH and RT-PCR from peripheral blood. Within the next 3 months, leukocytosis spontaneously subsided; however, BCR-ABL by RT-PCR and FISH was persistent both in peripheral blood and bone marrow. The patient was not started on any therapy and is being followed regularly with laboratory checkup and physical examination for monitoring signs and symptoms of chronic myeloid leukemia (CML) and biological behavior of his BCR-ABL transcripts. At 1 year of surveillance, he is disease free; however he has persistent detection of BCR-ABL fusion gene. Our case is challenging because actual risk of developing CML in BCR-ABL positive healthy, asymptomatic patients is not known.

摘要

我们报告一例39岁无症状男性病例，该患者偶然发现白细胞计数为15000/mm³，通过荧光原位杂交（FISH）和外周血逆转录聚合酶链反应（RT-PCR）检测发现，在300个细胞中有51个细胞存在BCR-ABL/t(9;22)(q34;q11)染色体易位阳性。在接下来的3个月内，白细胞增多症自行消退；然而，通过RT-PCR和FISH检测，外周血和骨髓中的BCR-ABL均持续存在。该患者未开始任何治疗，目前定期接受实验室检查和体格检查，以监测慢性髓性白血病（CML）的体征和症状以及其BCR-ABL转录本的生物学行为。在监测1年时，他没有疾病；然而，他持续检测到BCR-ABL融合基因。我们的病例具有挑战性，因为BCR-ABL阳性的健康无症状患者发生CML的实际风险尚不清楚。