Department of Pediatrics, Tai-Ann Hospital, Taipei, Taiwan.
J Microbiol Immunol Infect. 2009 Oct;42(5):371-7.
Adenoviruses are a common etiology of respiratory tract infections in children, with several serotypes responsible for most epidemic respiratory infections. This study examined the molecular epidemiology and clinical features of pediatric adenoviral infections in a 1-year period.
From May 1999 to April 2000, virus specimens collected from children with respiratory tract infections were identified. The presence of adenovirus was confirmed by direct fluorescent staining, and viral types were determined by polymerase chain reaction sequencing.
Adenoviruses were identified from 272 children (mean +/- standard deviation age, 48.3 +/- 30.5 months), 227 (83.5%) of whom were aged 6 years or younger. Inpatients were younger than outpatients (44.1 +/- 30.7 months vs 53.0 +/- 29.4 months; p = 0.006). The commonest serotype identified was serotype 3 (164 patients; 60.3%), 73.1% of which were identified between September 1999 and January 2000. Serotype 3 was more common in inpatients (p = 0.015), while serotypes 1, 2, 5, and 6 were more common in outpatients (p = 0.021). Patients with pneumonia were younger than those with other infections (31.8 +/- 20.2 months vs 50.3 +/- 31.0 months; p = 0.001). Most of the children (90.1%) had fever for a mean of 3.80 +/- 2.65 days before seeing a doctor. The clinical manifestations were similar regardless of the serotype.
Adenovirus serotype 3 caused the most adenovirus infections in autumn and winter of 1999 to 2000. The children were mostly preschool age and required hospital admission.
腺病毒是儿童呼吸道感染的常见病因，其中有几个血清型是引起大多数流行呼吸道感染的原因。本研究在一年内检测儿科腺病毒感染的分子流行病学和临床特征。
1999 年 5 月至 2000 年 4 月，采集呼吸道感染患儿的病毒标本，采用直接荧光染色法鉴定腺病毒，聚合酶链反应测序确定病毒型别。
共从 272 例患儿（平均年龄 48.3 ± 30.5 个月，范围 6 个月至 18 岁）中检出腺病毒，其中 227 例（83.5%）患儿年龄在 6 岁以下。住院患儿较门诊患儿年龄小（44.1 ± 30.7 个月 vs. 53.0 ± 29.4 个月，P = 0.006）。最常见的血清型为 3 型（164 例，60.3%），其中 73.1%于 1999 年 9 月至 2000 年 1 月检出。3 型在住院患儿中更常见（P = 0.015），而 1、2、5、6 型在门诊患儿中更常见（P = 0.021）。肺炎患儿较其他感染患儿年龄小（31.8 ± 20.2 个月 vs. 50.3 ± 31.0 个月，P = 0.001）。大多数患儿（90.1%）就诊前发热平均 3.80 ± 2.65 天。无论血清型如何，临床表现相似。
1999 年至 2000 年冬春季节，腺病毒 3 型引起的腺病毒感染最多。患儿以学龄前儿童为主，需住院治疗。
