Moulinoux J P, Darcel F, Quemener V, Havouis R, Seiler N
Groupe de Recherche en Thèrapeutique Anticancéreuse, CNRS SDI, Centre Hospitalier Universitaire de Rennes I, France.
Anticancer Res. 1991 Jan-Feb;11(1):175-9.
An almost complete prevention of tumor growth was achieved in U-251 human glioblastoma xenografted nude mice, by partial decontamination of the gastrointestinal tract and feeding of a polyamine-free diet containing inhibitors of ornithine decarboxylase (DFMO) and of polyamine oxidase (MDL 72527). After one week of polyamine deprivation, spermidine concentrations were lowered, and spermine levels were increased in all tissues. In contrast, putrescine concentrations were only reduced in tumor and in brain. Erythrocyte polyamine determinations revealed differences similar to those observed in tissues: spermidine concentration was lowered by 50% and spermine level was 3-fold increased. If this or related treatments should become of therapeutic importance in the future, then the determination of erythrocyte polyamine levels might be of diagnostic value.
通过部分净化胃肠道并喂食不含多胺且含有鸟氨酸脱羧酶抑制剂（DFMO）和多胺氧化酶抑制剂（MDL 72527）的饮食，在移植了U-251人胶质母细胞瘤的裸鼠中几乎完全抑制了肿瘤生长。多胺剥夺一周后，所有组织中的亚精胺浓度降低，精胺水平升高。相比之下，腐胺浓度仅在肿瘤和大脑中降低。红细胞多胺测定显示出与组织中观察到的差异相似：亚精胺浓度降低了50%，精胺水平增加了3倍。如果这种或相关治疗在未来具有治疗重要性，那么红细胞多胺水平的测定可能具有诊断价值。
