三乙基硅基醚的化学选择性脱保护
Chemoselective deprotection of triethylsilyl ethers.
作者信息
Chandra Tilak, Broderick William E, Broderick Joan B
机构信息
Department of Chemistry and Biochemistry Montana State University, Bozeman, MT 59717, USA.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2009 Nov;28(11):1016-29. doi: 10.1080/15257770903362172.
Abstract
An efficient and selective method was developed for the deprotection of triethylsilyl (TES) ethers using formic acid in methanol (5-10%) or in methylene chloride 2-5%) with excellent yields. TES ethers are selectively deprotected to the corresponding alcohols in high yields using formic acid in methanol under mild reaction conditions. Other hydroxyl protecting groups like t-butyldimethylsilyl (TBDMS) remain unaffected.
摘要
开发了一种高效且选择性的方法，用于使用甲醇（5 - 10%）或二氯甲烷（2 - 5%）中的甲酸对三乙基硅基（TES）醚进行脱保护，产率优异。在温和的反应条件下，使用甲醇中的甲酸可将TES醚选择性地高产率脱保护为相应的醇。其他羟基保护基团如叔丁基二甲基硅基（TBDMS）不受影响。
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