3-取代吡嗪酮核苷——一类新的司他夫定类似物。
3-Substituted pyrazinone nucleosides--a new family of D4T analogues.
作者信息
Batoux Nathalie, Granet Robert, Zerrouki Rachida, Krausz Pierre
机构信息
Laboratoire de Chimie des Substances Naturelles, Faculté des Sciences et Techniques, Universite de Limoges, Limoges, France.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2009 Sep;28(9):866-73. doi: 10.1080/15257770903169999.
The synthesis of a new family of D4T analogues is described to study the influence of pyrazinone base on antiretroviral power. Substitution of 3H by methyl or n-decyl increases the lipophilic character and may facilitate diffusion across cell membranes. The compounds were characterized by (1)H NMR and infrared spectroscopy. Antiviral (HIV-1) properties of these compounds were examined.
描述了一个新的二脱氧胸苷（D4T）类似物家族的合成，以研究吡嗪酮碱基对抗逆转录病毒能力的影响。用甲基或正癸基取代3H可增加亲脂性，并可能促进其跨细胞膜的扩散。这些化合物通过核磁共振氢谱（1H NMR）和红外光谱进行表征。检测了这些化合物的抗病毒（HIV-1）特性。
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