In vivo effects of repeated exposure of human neuroblastoma cell lines to deferoxamine.

Using an in vitro cytotoxicity assay method we examined the effects of three repeated exposures to 33 microM Deferoxamine on human neuroblastoma cell lines SK-N-DZ and VA-N-BR. There were no changes in cytolytic or cytostatic sensitivities in either cell line when compared to first time exposure. We conclude that tumor cell sensitivity may not be altered during repetitive spaced courses of deferoxamine in the clinical setting.