靛玉红衍生物对HL-60白血病细胞生长的抑制作用。
Inhibitory effects of indirubin derivatives on the growth of HL-60 leukemia cells.
作者信息
Cuong Nguyen Manh, Tai Bui Huu, Hoan Dang Hoang, Huong Tran Thu, Kim Young Ho, Hyun Jae-Hee, Kang Hee-Kyoung
机构信息
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Rd, Caugiay, Hanoi, Vietnam.
出版信息
Nat Prod Commun. 2010 Jan;5(1):103-6.
Six indirubin derivatives have been synthesized and their inhibitory effects on the growth of HL-60 human promyelocytic leukemia cells investigated. Cell viability was determined using the trypan blue exclusion method. Indirubin-3'-oxime (I-1) inhibited the growth of HL-60 cells with a GI50 value of 36.6 microM, whereas I-0, I-2, I-3, I-4 and I-6 showed only weak cytotoxic activities against HL-60 cancer cells with GI50 values in the range of 97.3 to over 100 microM. These results indicate that indirubin derivatives might be useful candidate agents for exploring potential antileukemic drugs.
已合成六种靛玉红衍生物，并研究了它们对HL-60人早幼粒细胞白血病细胞生长的抑制作用。使用台盼蓝排斥法测定细胞活力。靛玉红-3'-肟（I-1）对HL-60细胞生长具有抑制作用，其GI50值为36.6 microM，而I-0、I-2、I-3、I-4和I-6对HL-60癌细胞仅表现出微弱的细胞毒活性，GI50值在97.3至超过100 microM范围内。这些结果表明，靛玉红衍生物可能是探索潜在抗白血病药物的有用候选药物。
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