Ghorab Mostafa M, Ragab Fatma A, Heiba Helmy I, Youssef Hanan A, Galal Marwa
Department of Drug Radiation Research, National Center for Radiation Research and Technology, Atomic Energy Authority, Nasr City, Cairo, Egypt.
Arzneimittelforschung. 2010;60(1):48-55. doi: 10.1055/s-0031-1296248.
Several novel pyrazole (11-18) and pyrimidine (19-23) derivatives were synthesized starting from different sulfonamides and different active methylenes. The synthesized compounds were characterized by elemental analysis, IR, 1H-NMR and mass spectral data. The obtained compounds were screened as antitumor agents against human tumor cell line. Some of the tested compounds were equipotent while the others were more potent than doxorubicin (CAS 25316-40-9). The synergistic effect with gamma-radiation was also studied.
从不同的磺酰胺和不同的活性亚甲基出发，合成了几种新型吡唑衍生物（11 - 18）和嘧啶衍生物（19 - 23）。通过元素分析、红外光谱、¹H - 核磁共振和质谱数据对合成的化合物进行了表征。所得到的化合物被作为抗人肿瘤细胞系的抗肿瘤剂进行筛选。一些受试化合物具有同等效力，而其他一些化合物比阿霉素（CAS 25316 - 40 - 9）更有效。还研究了与γ射线的协同效应。
