Räsänen T
Second Department of Pathology, University of Helsinki, Helsinki, Finland.
Scand J Gastroenterol. 1967;2(2):118-23. doi: 10.3109/00365526709180056.
The responses of the gastric mucosal mast cells and the subcutaneous mast cells of the abdominal skin of the rat after administration of ACTH, heparin, and asbestos, were studied. The superficial part of the gastric mucosa contained roughly 5 times as many mast cells as the subcutaneous connective tissue. About three-fourths of the gastric mucosal mast cells were degranulated under the influence of ACTH, but the subcutaneous mast cells showed no changes in number and granulation. The observed difference indicates possibly that mast cells in the gastric mucosa and in the epidermis may have important special, but clearly differing, functions. In the gastric mucosa the sensitiveness of mast cells is possibly connected with their function as a peripheral mediator of stimulation of gastric secretion.
研究了给大鼠注射促肾上腺皮质激素（ACTH）、肝素和石棉后，其胃黏膜肥大细胞和腹部皮肤皮下肥大细胞的反应。胃黏膜浅层的肥大细胞数量大约是皮下结缔组织的5倍。约四分之三的胃黏膜肥大细胞在ACTH的影响下脱颗粒，但皮下肥大细胞的数量和颗粒情况没有变化。观察到的差异可能表明，胃黏膜和表皮中的肥大细胞可能具有重要的特殊但明显不同的功能。在胃黏膜中，肥大细胞的敏感性可能与其作为胃分泌刺激外周介质的功能有关。
