Department of Colorectal Surgery, PMAD, Beaujon Hospital, AP-HP, Clichy, France.
Colorectal Dis. 2011 Jun;13(6):684-8. doi: 10.1111/j.1463-1318.2010.02241.x. Epub 2010 Feb 20.
Colorectal cancer (CRC) complicating inflammatory bowel disease (IBD) accounts for 10-15% of all IBD deaths. Survival of patients with IBD-related CRC was reviewed to analyse differences between ulcerative colitis (UC) and Crohn's disease (CD).
We analysed (24 men and 10 women) patients with CD (n = 14) or UC (n = 20) with CRC, who presented between 1990 and 2007, and were followed to October, 2009.
The mean age of patients was 56 ± 12 years for patients with UC and 49 ± 17 years for patients with CD, and the mean duration of symptoms was 22 ± 11 and 16 ± 8 years, respectively. The median duration of follow up after the diagnosis of CRC was 49 (1-157) months. Recurrence occurred in five patients with UC and in nine with CD (P = 0.02). The overall and disease free five year survivals were significantly higher in patients with UC than CD [70%vs 43% (P = 0.01) and 63%vs 31% (P = 0.01), respectively].
The results showed a poorer prognosis of CRC in patients with CD than with UC.
炎症性肠病（IBD）并发结直肠癌（CRC）占所有 IBD 死亡人数的 10-15%。对 IBD 相关 CRC 患者的生存情况进行了回顾性分析，以分析溃疡性结肠炎（UC）和克罗恩病（CD）之间的差异。
我们分析了 1990 年至 2007 年间就诊的患有 CD（n = 14）或 UC（n = 20）合并 CRC 的患者（24 名男性和 10 名女性），并随访至 2009 年 10 月。
UC 患者的平均年龄为 56 ± 12 岁，CD 患者的平均年龄为 49 ± 17 岁，症状持续时间分别为 22 ± 11 年和 16 ± 8 年。CRC 诊断后中位随访时间为 49（1-157）个月。UC 组中有 5 例患者和 CD 组中有 9 例患者出现复发（P = 0.02）。UC 组的总生存率和无病生存率明显高于 CD 组[70%vs 43%（P = 0.01）和 63%vs 31%（P = 0.01）]。
结果表明 CD 患者 CRC 的预后较 UC 患者差。
