Laboratory of Biophysics, Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia.
J Biomech. 2010 May 28;43(8):1612-7. doi: 10.1016/j.jbiomech.2009.12.026. Epub 2010 Feb 25.
It is indicated that nonhomogeneous lateral distribution of membrane attached and flexible rod-like proteins (MRPs) may stabilize nanotubular membrane protrusions. We have shown that curvature induced accumulation of MRPs in the nanotubular membrane protrusion and the corresponding reduction of the membrane free energy are possible if the decrease of the deviatoric free energy of MRPs in the nanotubular protrusions is large enough to overcome the increase of the free energy due to decrease of configurational entropy in the process of lateral sorting of MRPs. The decrease of isotropic curvature energy of MRPs in the region of membrane protrusion is usually not sufficient for substantial MRPs sorting and consequent stabilization of the nanotubular membrane protrusions.
有迹象表明，膜结合的和柔性棒状蛋白（MRP）的非均匀横向分布可能稳定管状膜突。我们已经表明，如果在管状突起中 MRP 的各向异性曲率自由能的降低足以克服由于 MRP 的横向排序过程中构象熵的降低而导致的自由能的增加，那么曲率诱导的 MRP 在管状突起中的积累以及相应的膜自由能的降低是可能的。MRP 在膜突起区域的各向同性曲率能量的降低通常不足以进行大量的 MRP 排序，并因此稳定管状膜突起。
