Cardiovascular Division, Department of Medicine, Cardiac Arrhythmia Center, University of Minnesota Medical School, MMC 508, 420 Delaware Street SE, Minneapolis, MN 55455, USA.
Europace. 2010 Jun;12(6):905-7. doi: 10.1093/europace/euq034. Epub 2010 Feb 25.
The characteristic electrocardiographic (ECG) findings of Brugada syndrome, specifically the down sloping coved elevation of the ST-segment ending in an inverted T-wave in the right precordial leads, have been linked to reduced inward sodium current due to dysfunctional sodium channels. Additionally, however, many sodium channel blocking agents are known to either unmask or induce this ECG pattern. Severe hyponatraemia may be expected to have the same effect by reducing inward sodium current. Here, we report a case in which the presenting ECG exhibited a 'Brugada-like' pattern during severe isolated hyponatraemia, with subsequent normalization as hyponatraemia improved.
Brugada 综合征的特征性心电图(ECG)表现,特别是右胸前导联的 ST 段下斜抬高终末倒置 T 波,与功能障碍的钠通道导致内向钠电流减少有关。然而,许多钠通道阻滞剂已知要么掩盖要么诱导这种 ECG 模式。严重低钠血症预计也会通过减少内向钠电流产生同样的效果。在这里,我们报告了一例在严重孤立性低钠血症期间出现“Brugada 样”心电图表现的病例,随着低钠血症的改善,随后恢复正常。