Department of Dermatology, Amiens University Medical Centre, South Hospital, Amiens, France. Florie.Dhaille @ orange.fr
Dermatology. 2010;220(3):234-7. doi: 10.1159/000275676. Epub 2010 Feb 20.
We report two cases of cutaneous granuloma induced by anti-TNF-alpha therapy: a 47-year-old man suffering from psoriatic arthritis treated with infliximab and a 56-year-old woman treated with adalimumab for polyarticular juvenile rheumatoid arthritis. The biospies confirmed the diagnosis of a 'sarcoidosis-like' reaction. No systemic involvement was observed. Such cases of noninfectious granulomatous diseases occurring during anti-TNF-alpha therapy are becoming increasingly frequent.
我们报告了两例由抗 TNF-α 治疗引起的皮肤肉芽肿病例：一例是 47 岁患有银屑病关节炎的男性，接受英夫利昔单抗治疗；另一例是 56 岁患有多关节幼年特发性关节炎的女性，接受阿达木单抗治疗。活检证实了“类肉瘤样”反应的诊断。未观察到全身受累。在抗 TNF-α 治疗期间发生的此类非传染性肉芽肿性疾病的病例越来越多。
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