Allergy Unit, Department of Dermatology, University Hospital Basel, Basel, Switzerland.
Dermatology. 2010;220(3):238-42. doi: 10.1159/000275703. Epub 2010 Feb 25.
We report a case of severe contact urticaria with systemic involvement resembling an anaphylactic reaction, following the application of a topical corticosteroid. This was caused by hexylene glycol, an excipient in the formulation. Glycols are widely used in cosmetics, foods and topical and systemic drugs. In particular, glycols are present in many topical drugs used by dermatologists. To our knowledge, this is the first case in the literature of a potentially life-threatening immediate-type reaction in the context of a contact urticaria syndrome due to hexylene glycol. The classification of contact urticaria syndrome and the allergenic potential of glycols are reviewed. Dermatologists should be aware of the contact urticaria syndrome and of the increasing use of glycols in topical drug formulation in order to identify possible adverse reactions.
我们报告了一例严重的接触性荨麻疹，伴有全身性受累，类似于过敏反应，发生于局部应用皮质类固醇后。这是由配方中的一种辅料己二醇引起的。二醇广泛用于化妆品、食品以及局部和全身药物。特别是，二醇存在于皮肤科医生使用的许多局部药物中。据我们所知，这是文献中首例由于己二醇引起的接触性荨麻疹综合征的潜在危及生命的即刻型反应。本文回顾了接触性荨麻疹综合征的分类和二醇的变应原性。皮肤科医生应该了解接触性荨麻疹综合征和局部药物配方中二醇的使用日益增加，以便识别可能的不良反应。
