更好的肾脏病学研究——惠及老鼠和人类。
Better nephrology for mice--and man.
机构信息
Biotechnology Discovery Research, Lilly Research Laboratories, Indianapolis, Indiana 46285, USA.
出版信息
Kidney Int. 2010 Mar;77(6):487-9. doi: 10.1038/ki.2009.544.
PMID:20186162
Abstract
The use of creatinine to estimate glomerular filtration rate in patients is prone to well-described artifacts that impact its interpretation. Eisner et al. now show that the impact of creatinine secretion on creatinine clearance is even larger in mice than in humans, raising questions regarding the utility of creatinine for measuring glomerular filtration rate in mice.
摘要
在患者中使用肌酐估计肾小球滤过率容易受到描述明确的人为因素的影响，这些因素会影响其解读。Eisner 等人现在表明，在小鼠中，肌酐分泌对肌酐清除率的影响甚至比在人类中更大，这引发了关于肌酐在测量小鼠肾小球滤过率中的效用的问题。
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