Ogundele Abayomi B, Li Guangming, Ellis Joel J
Alcon Research, Ltd., Fort Worth, TX, USA.
Clin Ophthalmol. 2010 Feb 18;4:77-80. doi: 10.2147/opth.s9826.
The purpose of this study was to examine and compare the conjunctival irritation (congestion, swelling, and discharge) of topical bimatoprost ophthalmic solution 0.01% and bimatoprost ophthalmic solution 0.03% in rabbits.
Six healthy New Zealand White rabbits were treated with either bimatoprost 0.01% or bimatoprost 0.03% (3 animals/group). One dose (2 drops/dose) of study medication was administered to the right eye of each animal every 30 minutes for 4.5 hours. Approximately 1 hour after the last dose, conjunctival irritation was assessed using a slit-lamp biomicroscope to individually evaluate conjunctival congestion, swelling, and discharge.
The mean conjunctival congestion, swelling and discharge scores for bimatoprost 0.03% were 1.67, 0.33 and 0.33, respectively, and for bimatoprost 0.01% were 2.00, 0.33 and 1.33, respectively.
Despite the lower drug concentration of the 0.01% formulation, bimatoprost 0.01% does not reduce conjunctival irritation, including conjunctival congestion, swelling, and discharge, in rabbits compared to bimatoprost 0.03%. Further studies would be needed to determine whether the increase in the mean conjunctival congestion and discharge scores may be attributed to the increased BAK concentration in the bimatoprost 0.01% formulation.
本研究的目的是检查并比较0.01%的比马前列素滴眼液和0.03%的比马前列素滴眼液对兔结膜的刺激作用（充血、肿胀和分泌物）。
六只健康的新西兰白兔，分别用0.01%的比马前列素或0.03%的比马前列素进行治疗（每组3只动物）。每只动物的右眼每隔30分钟给予一剂（2滴/剂）研究药物，共给药4.5小时。最后一剂给药后约1小时，使用裂隙灯生物显微镜评估结膜刺激情况，以分别评估结膜充血、肿胀和分泌物。
0.03%的比马前列素的结膜充血、肿胀和分泌物平均评分分别为1.67、0.33和0.33，0.01%的比马前列素的相应评分为2.00、0.33和1.33。
尽管0.01%制剂的药物浓度较低，但与0.03%的比马前列素相比，0.01%的比马前列素在兔中并未减轻结膜刺激，包括结膜充血、肿胀和分泌物。需要进一步研究以确定结膜充血和分泌物平均评分的增加是否可能归因于0.01%比马前列素制剂中苯扎氯铵浓度的增加。
