Dong Rui-zeng, Shi Ying-qiang, Ye Yan-wei, Fu Hong, Zhao Guang-fa
Department of Abdominal Surgery, Cancer Hospital, Fudan University, Shanghai, China.
Zhonghua Wei Chang Wai Ke Za Zhi. 2010 Feb;13(2):125-8.
To study the incidence, clinicopathological characteristics, diagnosis, treatment, and prognosis of synchronous or metachronous primary cancers in patients with gastric cancer.
Clinical data of 4426 patients with gastric cancer in our hospital from 1996 to 2007 were reviewed.
Seventy-four (1.7%) patients had synchronous or metachronous primary cancer of other organ, of whom 10 were synchronous and 64 were metachronous. Colorectal cancer was the most common type of primary cancer in other organs (43.8%), followed by breast cancer (16.3%). The mean time interval between gastric cancer and metachronous primary cancer was 82.2 (3-354) months. The mean age at the diagnosis of gastric cancer was 61.2 (33-84) years. The 5-year overall survival rate was 42.3%. The 5-year survival rates in patients with synchronous cancer, pre-metachronous cancer or post-metachronous cancer were 15.2%, 42.9% and 51.3%, respectively. Causes of death were primary cancers of other organ in 11 patients, gastric cancer in 24, and renal failure in 1 patient.
Primary cancer of other organ should be considered in the management of gastric cancer. Aggressive treatment should be used for the second primary cancer. Gastric cancer is the main cause of death in these patients.
研究胃癌患者同时性或异时性原发性癌的发病率、临床病理特征、诊断、治疗及预后。
回顾性分析我院1996年至2007年4426例胃癌患者的临床资料。
74例（1.7%）患者患有其他器官的同时性或异时性原发性癌，其中10例为同时性，64例为异时性。结直肠癌是其他器官原发性癌最常见的类型（43.8%），其次是乳腺癌（16.3%）。胃癌与异时性原发性癌之间的平均时间间隔为82.2（3 - 354）个月。胃癌诊断时的平均年龄为61.2（33 - 84）岁。5年总生存率为42.3%。同时性癌、异时性癌前或异时性癌后患者的5年生存率分别为15.2%、42.9%和51.3%。死亡原因：11例为其他器官原发性癌，24例为胃癌，1例为肾衰竭。
在胃癌的治疗中应考虑其他器官的原发性癌。对第二原发性癌应采取积极的治疗措施。胃癌是这些患者的主要死亡原因。
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