Ikeguchi M, Ohfuji S, Oka A, Tsujitani S, Maeda M, Kaibara N
Department of Surgery I, Faculty of Medicine, Tottori University.
Hepatogastroenterology. 1995 Sep-Oct;42(5):672-6.
BACKGROUND/AIMS: We investigated the outcomes of patients with early gastric cancer, with special reference to the prognosis of patients with synchronous or metachronous primary malignancies in organs other than the stomach.
Among 890 patients with early gastric cancer, 97 (10.9%) had synchronous or metachronous primary malignancies in organs other than the stomach. Ten-year survival rates were compared between patients who had additional malignancies and patients who had early gastric cancer but no other malignant disease (control group).
Synchronous primary malignancies were detected in 32 patients and metachronous primary malignancies were detected in 65 patients (17 had developed before gastrectomy and 48 developed after gastrectomy). Hepatic cell carcinoma, lung cancer and colorectal cancer were frequently detected between 2 and 24 years after gastrectomy. The 10-year survival rate was 80.8% for 769 patients in the control group but it was only 49.7% for the 92 patients with additional malignancies. Moreover, metachronous malignant disease was found more over 10 years after gastrectomy in 30 of the 48 cases (62.5%).
These results suggest the importance of long-term follow-up for detection of metachronous carcinomas at sites other than the stomach for patients with early gastric cancer.
背景/目的：我们对早期胃癌患者的预后进行了研究，特别关注胃外器官同时性或异时性原发性恶性肿瘤患者的预后情况。
在890例早期胃癌患者中，97例（10.9%）在胃外器官存在同时性或异时性原发性恶性肿瘤。比较了合并其他恶性肿瘤的患者与仅患有早期胃癌而无其他恶性疾病的患者（对照组）的10年生存率。
32例患者检测到同时性原发性恶性肿瘤，65例患者检测到异时性原发性恶性肿瘤（17例在胃切除术前发生，48例在胃切除术后发生）。肝细胞癌、肺癌和结直肠癌常在胃切除术后2至24年被检测到。对照组769例患者的10年生存率为80.8%，而92例合并其他恶性肿瘤的患者的10年生存率仅为49.7%。此外，48例异时性恶性疾病患者中有30例（62.5%）是在胃切除术后10年以上被发现的。
这些结果表明，对早期胃癌患者进行长期随访以检测胃外部位的异时性癌具有重要意义。
