Center for Musculoskeletal Surgery, University Charité, Berlin, Germany.
J Magn Reson Imaging. 2010 Mar;31(3):636-44. doi: 10.1002/jmri.22074.
To develop a signal-inducing bone cement for musculoskeletal procedures in magnetic resonance imaging (MRI).
Acrylic resins were mixed with contrast agents (CAs) and water. We determined the ideal concentration of the components and assessed feasibility in cadaveric bones in an open high-field MR scanner. The contrast-to-noise ratio (CNR) in air and bone was evaluated and mechanical tests were achieved. We determined the amount of water that was not incorporated and measured the amount of CA released with photometric analysis. The cement was analyzed microscopically.
Preparation and application of the CA-water-cement compound was feasible and its differentiation in MRI was clear. The maximal CNR(air) had a value of 157.5 (SD 18.3) in an interventional fast T1W turbo-spin echo (TSE) sequence. The compressive strength decreased with the amount of water added. Although nearly 50% of the water added was not incorporated in the cement, the CNR was sufficient for cement detection. The threshold for systemic toxicity of delivered CA was not reached and the microscopic analysis showed water bubbles in the cement.
A signal-inducing bone cement is feasible for the use in MRI.
开发一种用于磁共振成像（MRI）中肌肉骨骼手术的信号诱导骨水泥。
将丙烯酸树脂与对比剂（CA）和水混合。我们确定了各成分的理想浓度，并在开放式高场强磁共振扫描仪中的尸体骨头上评估了其可行性。评估了空气中和骨中的对比噪声比（CNR），并进行了机械测试。我们确定了未结合的水量，并通过光密度分析测量了释放的 CA 量。对水泥进行了显微镜分析。
CA-水-水泥化合物的制备和应用是可行的，其在 MRI 中的分化是清晰的。在介入性快速 T1W 涡轮自旋回波（TSE）序列中，最大 CNR（空气）值为 157.5（SD 18.3）。随着添加水量的增加，抗压强度降低。尽管添加的水中有近 50％未结合到水泥中，但 CNR 足以检测水泥。未达到输送 CA 的全身毒性阈值，显微镜分析显示水泥中有水气泡。
一种可用于 MRI 的信号诱导骨水泥是可行的。
