Averina E S, Seewald G, Müller R H, Radnaeva L D, Popov D V
Baikal Institute of Nature Management, Siberian Branch of Russian Academy of Science, Ulan-Ude, Russia.
Pharmazie. 2010 Jan;65(1):25-31.
Nanostructured lipid carriers (NLC) are new drug systems composed of physiological lipid materials. The possibility of including different types of lipids into the NLC structure revealed the wide prospects for using biologically active natural oils for the development of the cutaneous preparations. In this study the formulation parameters of NLC on the basis of Siberian pine seed oil were evaluated including concentration of lipids, types of surfactants and storage conditions (4 degrees C, 20 degrees C, 40 degrees C). Size distribution and storage stability of formulations produced by hot high pressure homogenisation were investigated by laser diffractometry and photon correlation spectroscopy. The NLC were characterised by their melting behaviour using differential scanning calorimetry. The obtained data indicated the high physical stability of the developed NLC formulations.
纳米结构脂质载体（NLC）是由生理脂质材料组成的新型药物系统。将不同类型的脂质纳入NLC结构的可能性揭示了使用生物活性天然油开发皮肤制剂的广阔前景。在本研究中，评估了基于西伯利亚松子油的NLC的配方参数，包括脂质浓度、表面活性剂类型和储存条件（4℃、20℃、40℃）。通过激光衍射法和光子相关光谱法研究了热高压均质法制备的制剂的粒径分布和储存稳定性。使用差示扫描量热法对NLC的熔化行为进行了表征。所得数据表明所开发的NLC制剂具有很高的物理稳定性。
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