Poonia Neelam, Kharb Rajeev, Lather Viney, Pandita Deepti
Department of Pharmaceutics, JCDM College of Pharmacy, Sirsa 125055, Haryana, India; Department of Pharmaceutics, JCDM College of Pharmacy, Sirsa 125055, Haryana, India.
Department of Pharmaceutical Chemistry, CT Institute of Pharmaceutical Sciences, Jalandhar 144020, Punjab, India; Department of Pharmaceutical Chemistry, CT Institute of Pharmaceutical Sciences, Jalandhar 144020, Punjab, India.
Future Sci OA. 2016 Jul 15;2(3):FSO135. doi: 10.4155/fsoa-2016-0030. eCollection 2016 Sep.
Oral delivery is the most accepted and economical route for drug administration and leads to substantial reduction in dosing frequency. However, this route still remains a challenge for the pharmaceutical industry due to poorly soluble and permeable drugs leading to poor oral bioavailability. Incorporating bioactives into nanostructured lipid carriers (NLCs) has helped in boosting their therapeutic functionality and prolonged release from these carrier systems thus providing improved pharmacokinetic parameters. The present review provides an overview of noteworthy studies reporting impending benefits of NLCs in oral delivery and highlights recent advancements for developing engineered NLCs either by conjugating polymers over their surface or modifying their charge to overcome the mucosal barrier of GI tract for active transport across intestinal membrane.
口服给药是最被广泛接受且经济的给药途径，可大幅减少给药频率。然而，由于药物溶解性和渗透性差导致口服生物利用度低，该途径对制药行业来说仍是一项挑战。将生物活性物质纳入纳米结构脂质载体（NLCs）有助于增强其治疗功能，并延长从这些载体系统中的释放时间，从而提供更好的药代动力学参数。本综述概述了报道NLCs在口服给药中潜在益处的重要研究，并强调了通过在其表面缀合聚合物或改变其电荷来开发工程化NLCs的最新进展，以克服胃肠道的粘膜屏障，实现跨肠膜的主动转运。
