双频谱指数与健康志愿者靶控输注异丙酚镇静不同深度时效应室预测浓度的相关性。

Correlation between bispectoral index and predicted effect-site concentration of propofol in different levels of target-controlled, propofol induced sedation in healthy volunteers.

机构信息

Department of Anesthesiology and Intensive Care, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.

出版信息

Arch Iran Med. 2010 Mar;13(2):126-34.

PMID:20187667

Abstract

INRODUCTION

Bispectral Index is an objective tool to assess electroencephalographic activity and measure the effect of certain sedatives and hypnotics on the brain. In addition, there are certain subjective tools such as the observer's assessment of alertness and sedation which are used. The correlation between BIS and the concentration of propofol in the brain, and the relationship between these subjective and objective tools in assessing sedation levels are the subject of this study.

METHODS

Thirty healthy volunteers enrolled in this prospective observational study. They were sedated with a target controlled infusion of propofol with an initial target of 0.8 microg.mL(-1)and an increase in target to 0.2 microg.mL(-1) ten minutes after equilibration of the predicted and set target concentrations. In each sedation score, the Bispectral Index value and predicted effect site concentration of propofol were recorded and analyzed. Analysis of variance and significant differences between groups were analyzed by paired t-test. Correlations between Bispectral Index and effect site concentration of propofol at each sedation score and the relationship of BIS and effect site concentration of propofol to each sedation score were assessed and analyzed by nonparametric Spearman's rho.

RESULTS

The means of Bispectral Index and effect site concentration of propofol at each sedation score showed a significant difference with the following score. Additionally, Bispectral Index and effect site concentration of propofol showed a significant negative correlation in sedation scores 3 and 2 when inducing sedation. In other sedation scores or when reversing the sedation, no strong correlation was noted.

CONCLUSION

Both Bispectral Index and effect site concentration of propofol indicate a good estimate of sedation levels; however their correlations are significant and negative only at moderate and deep sedation levels, and during the induction of sedation.

摘要

简介

双频谱指数是一种评估脑电图活动并测量某些镇静剂和催眠药对大脑影响的客观工具。此外，还使用了一些主观工具，如观察者对警觉性和镇静程度的评估。本研究的主题是 BIS 与脑内丙泊酚浓度之间的相关性，以及这些评估镇静水平的主观和客观工具之间的关系。

方法

30 名健康志愿者参与了这项前瞻性观察研究。他们接受丙泊酚靶控输注镇静，初始靶浓度为 0.8μg/ml，平衡预测浓度和设定浓度 10 分钟后靶浓度增加至 0.2μg/ml。在每个镇静评分中，记录并分析了双频谱指数值和预测的丙泊酚效应部位浓度。通过配对 t 检验分析方差和组间差异。通过非参数 Spearman's rho 评估和分析了每个镇静评分下 BIS 和丙泊酚效应部位浓度之间的相关性，以及 BIS 和丙泊酚效应部位浓度与每个镇静评分之间的关系。