[HIV-1潜伏的分子基础 - 第一部分：HIV-1潜伏的生理学]

[Molecular basis of HIV-1 latency - part I: physiology of HIV-1 latency].

作者信息

Schwartz Christian, Le Douce Valentin, Cherrier Thomas, Redel Laetitia, Marban Céline, Aunis Dominique, Rohr Olivier

机构信息

Inserm Unité 575 Physiopathologie du système nerveux central, Institut de virologie, Strasbourg, France.

出版信息

Med Sci (Paris). 2010 Feb;26(2):159-63. doi: 10.1051/medsci/2010262159.

DOI:10.1051/medsci/2010262159

PMID:20188047

Abstract

The introduction of the highly active antiretroviral therapy (HAART) in 1996 has greatly extended survival and raised hopes for the eradication of HIV-1. Unfortunately, the optimism declined by revealing the existence of latent HIV-1 reservoirs in cells targeted by the virus. The long-lived HIV-1 reservoirs constitute a major obstacle to the eradication of HIV-1. Understanding the molecular mechanisms of virus latency is essential for efficient therapeutic intervention against the virus.

摘要

1996年高效抗逆转录病毒疗法（HAART）的引入极大地延长了患者生存期，并为根除HIV-1带来了希望。不幸的是，随着病毒靶向细胞中潜伏HIV-1储存库的发现，这种乐观情绪有所下降。长期存在的HIV-1储存库是根除HIV-1的主要障碍。了解病毒潜伏的分子机制对于有效治疗该病毒至关重要。