Department of Biological and Clinical Psychology, Friedrich-Schiller-University of Jena, Am Steiger 3//1, D-07743 Jena, Germany.
Neuropsychologia. 2010 May;48(6):1735-41. doi: 10.1016/j.neuropsychologia.2010.02.022. Epub 2010 Feb 24.
An influential single case study (Calder, Keane, Manes, Antoun, & Young, 2000, Nature Neuroscience, 3, 1077-1078) recently showed a marked multimodal impairment in the recognition and experience of disgust in a patient with a left-hemispheric lesion of the basal ganglia and the insular cortex. Here, we investigated whether a similar deficit will be observed in a patient with a comparable lesion of the insula and basal ganglia in the right hemisphere. Remarkably, the patient showed no impairments in the recognition or experience of disgust and also no notable impairments in the recognition and experience of other emotions, across a range of stimuli, as compared to healthy comparison subjects. Thus, either deficits in disgust processing are not reliably observed in patients with lesion of the insula and basal ganglia regardless of the laterality of the lesion; or right-hemispheric lesions, in contrast to left-hemispheric lesions, do not seem to induce impairments in the processing of disgust.
最近一项有影响力的单病例研究（Calder、Keane、Manes、Antoun 和 Young，2000，《自然神经科学》，3，1077-1078）表明，一名左侧基底节和岛叶损伤的患者在识别和体验厌恶感方面存在明显的多模式障碍。在这里，我们研究了在右侧半球具有类似岛叶和基底节损伤的患者中是否会观察到类似的缺陷。值得注意的是，与健康对照组相比，该患者在识别或体验厌恶感方面没有任何缺陷，并且在识别和体验其他情绪方面也没有明显缺陷，涉及一系列刺激。因此，无论损伤的侧别如何，岛叶和基底节损伤的患者中并不可靠地观察到厌恶处理缺陷；或者右半球损伤，与左半球损伤相反，似乎不会导致厌恶感处理受损。
