Department of Molecular Biology and Immunology, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA.
Brain Res Bull. 2010 Apr 29;82(1-2):83-6. doi: 10.1016/j.brainresbull.2010.02.007. Epub 2010 Feb 24.
Thyrotropin-releasing hormone (TRH, pGlu-His-Pro-NH(2)) and the structurally related [Glu(2)]TRH (pGlu-Glu-Pro-NH(2)) are endogenous peptides with a plethora of actions in the central nervous system. Many centrally-mediated effects of TRH are shared with those of [Glu(2)]TRH, although the involvement of different receptors is presumed. The analeptic action is the best-known TRH-related central nervous system effect. While [Glu(2)]TRH itself is analeptic, its co-administration with TRH into mice produced a dose-dependent attenuation of TRH-evoked reversal of barbiturate-induced sleeping time. This finding is in agreement with our previous observations that [Glu(2)]TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. Taken together, [Glu(2)]TRH may be considered as a negative modulator for the cholinergic effect of TRH in the mouse brain.
促甲状腺激素释放激素（TRH，pGlu-His-Pro-NH2）和结构相关的[Glu2]TRH（pGlu-Glu-Pro-NH2）是内源性肽，在中枢神经系统中有多种作用。TRH 的许多中枢介导作用与[Glu2]TRH 共享，尽管假定涉及不同的受体。催醒作用是 TRH 相关的中枢神经系统作用中最著名的一种。虽然[Glu2]TRH 本身具有催醒作用，但将其与 TRH 一起给予小鼠会导致 TRH 诱发的巴比妥酸盐诱导睡眠时间逆转的剂量依赖性减弱。这一发现与我们之前的观察结果一致，即[Glu2]TRH 显著减弱 TRH 诱导的海马细胞外乙酰胆碱释放。总之，[Glu2]TRH 可被视为小鼠脑内 TRH 胆碱能作用的负调节剂。
