触觉预期调节人类感觉运动皮层的预刺激β波段振荡。

Tactile expectation modulates pre-stimulus beta-band oscillations in human sensorimotor cortex.

机构信息

Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.

出版信息

Neuroimage. 2010 Jun;51(2):867-76. doi: 10.1016/j.neuroimage.2010.02.053. Epub 2010 Feb 24.

Abstract

Neuronal oscillations are postulated to play a fundamental role in top-down processes of expectation. We used magnetoencephalography (MEG) to investigate whether expectation of a tactile event involves a pre-stimulus modulation of neuronal oscillations in human somatosensory cortex. In a bimodal attention paradigm, participants were presented with a predictable spatio-temporal pattern of lateralized tactile stimulations and simultaneously occurring non-lateralized auditory stimuli. Before the onset of a series of such combined audio-tactile stimuli, a cue was presented that indicated the sensory stream that had to be attended. By investigating lateralized patterns of oscillatory activity, we were able to study both attentive (when the tactile stream was attended) and non-attentive (when the auditory stream was attended) tactile expectations. For both attention conditions, we observed a lateralized modulation of the amplitude of beta band oscillations prior to a predictable - and accordingly lateralized - tactile stimulus. As such, we show that anticipatory modulation of ongoing oscillatory activity is not restricted to attended sensory events. Attention did enlarge the size of this modulation. We argue that this modulation constitutes a suppression of beta oscillations that originate at least partly from primary somatosensory cortex (S1) contralateral to the expected stimulation. We discuss our results in the light of the hypothesis that ongoing beta oscillations over sensorimotor cortex reflect a brain state in which neuronal processing efficacy is low. Pre-stimulus suppression of these oscillations then prepares the system for future processing. This shows that perception is an active process that starts even prior to sensation.

摘要

神经元振荡被假设在自上而下的期望过程中发挥基本作用。我们使用脑磁图(MEG)研究了对触觉事件的期望是否涉及人类体感皮层中神经元振荡的预刺激调制。在双模态注意范式中,参与者接受了可预测的空间时间模式的偏侧化触觉刺激和同时发生的非偏侧化听觉刺激。在一系列这种组合的音频触觉刺激开始之前,会出现一个提示,指示必须注意的感觉流。通过研究振荡活动的偏侧化模式,我们能够研究有注意(当触觉流被注意时)和无注意(当听觉流被注意时)的触觉期望。对于这两种注意条件,我们在可预测的(因此是偏侧化的)触觉刺激之前观察到β波段振荡幅度的偏侧化调制。因此,我们表明,对正在进行的振荡活动的预期调制不仅限于被注意的感觉事件。注意力确实扩大了这种调制的大小。我们认为,这种调制构成了对源自预期刺激对侧的初级体感皮层(S1)的β振荡的抑制。我们根据假设讨论了我们的结果,即体感皮层上的持续β振荡反映了一种大脑状态,其中神经元处理效率较低。这些振荡的预刺激抑制然后为未来的处理做好准备。这表明感知是一个主动的过程,甚至在感觉之前就已经开始了。

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