Laboratorio de Esteroides, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Buenos Aires, Buenos Aires, Argentina.
Fertil Steril. 2010 Oct;94(5):1933-6. doi: 10.1016/j.fertnstert.2010.01.039. Epub 2010 Feb 26.
As we previously reported, testes of men suffering from hypospermatogenesis and germ cell arrest or Sertoli cell-only syndrome show a major increase in the number of macrophages expressing interleukin-1β (IL-1β) and abundant expression of cyclooxygenase-2 (COX-2), the inducible isoform of the key enzyme in the biosynthesis of prostaglandins (PGs), in Leydig cells. In the present study we report [1] a positive correlation between IL-1β levels and COX-2 expression in testes of infertile patients, [2] the induction of COX-2 by IL-1β in mouse Leydig cells (TM3) and human macrophages (THP-1), and therefore [3] evidence for an IL-1β-dependent induction of testicular inflammatory states.
如我们之前报道的，患有精子发生减少症和精母细胞阻滞或唯支持细胞综合征的男性的睾丸中，表达白细胞介素-1β（IL-1β）的巨噬细胞数量明显增加，并且在睾丸间质细胞中环氧合酶-2（COX-2），即前列腺素（PGs）生物合成中的关键酶的诱导型同工酶，表达丰富。在本研究中，我们报道 [1] 不育患者睾丸中 IL-1β 水平与 COX-2 表达之间呈正相关，[2] IL-1β 在小鼠睾丸间质细胞（TM3）和人巨噬细胞（THP-1）中诱导 COX-2 的表达，因此 [3] 存在 IL-1β 依赖性诱导睾丸炎症状态的证据。
