Krogstad D J, Sutera S P, Boylan C W, Gluzman I Y, Qian Z F, Rao P R
Department of Medicine, Washington University, St. Louis, MO 63110.
Blood Cells. 1991;17(1):209-21; discussion 222-7.
In the studies reported here, we examined the effects of two intraerythrocytic parasites (Plasmodium berghei and Babesia microti) on the deformability of their host red cells. Red cell deformability was assessed by three criteria: 1) the prevalence of tank-treading (the tank-tread-like movement of the red cell membrane around its cytoplasmic contents), 2) elongation under fluid shear stress (the steady-state length: width ratio), and 3) the time required for the red cell to reduce its steady-state elongation by 63.2% after the abrupt release of the shear stress (the characteristic shape-recovery time). Trophozoite-stage parasites of both species reduced the prevalence of tank-treading. Ring- and trophozoite-stage parasites of both species reduced steady-state elongation, and ring-stage P. berghei prolonged the shape-recovery time. These results suggest that altered red cell deformability is a common feature of infection with intraerythrocytic parasites.
在本文报道的研究中，我们检测了两种红细胞内寄生虫（伯氏疟原虫和微小巴贝斯虫）对其宿主红细胞变形性的影响。通过三个标准评估红细胞变形性：1）坦克履带式运动的发生率（红细胞膜围绕其细胞质内容物的类似坦克履带式运动），2）流体剪切应力下的伸长率（稳态长宽比），以及3）在突然释放剪切应力后红细胞将其稳态伸长率降低63.2%所需的时间（特征形状恢复时间）。两种物种的滋养体阶段寄生虫均降低了坦克履带式运动的发生率。两种物种的环状体和滋养体阶段寄生虫均降低了稳态伸长率，且环状体阶段的伯氏疟原虫延长了形状恢复时间。这些结果表明，红细胞变形性改变是红细胞内寄生虫感染的一个共同特征。
