Department of Radiation Oncology, University of Arizona, Tucson, AZ 85724-5081, USA.
Oral Oncol. 2010 Apr;46(4):283-6. doi: 10.1016/j.oraloncology.2010.01.010. Epub 2010 Feb 25.
We would like to compare the effectiveness of image-guided (IGRT) and intensity-modulated (IMRT) radiotherapy to spare the larynx in head and neck cancer patients. A retrospective review of 48 patients undergoing radiation for non-laryngeal and non-hypopharyngeal head and neck cancers. Mean laryngeal and hypopharyngeal dose was compared between 11 patients treated with IMRT and 37 patients treated with IGRT. Mean laryngeal dose was, respectively, 41.2 Gy and 22.8 Gy for the IMRT and IGRT technique (p<0.001). The radiation dose to the middle and inferior pharyngeal muscles was also significantly reduced with the IGRT technique. Mean pharyngeal dose was, respectively, 52 Gy and 26 Gy for the IMRT and IGRT technique (p=0.0001). Laryngeal sparing IGRT technique for head and neck cancer minimizes radiotherapy dose to the larynx and pharynx without sacrificing target coverage, even in the presence of neck lymph nodes.
我们希望比较图像引导（IGRT）和强度调制（IMRT）放疗在头颈部癌症患者中保护喉的效果。对 48 例接受非喉和非下咽头颈部癌症放疗的患者进行回顾性分析。比较了 11 例接受 IMRT 治疗和 37 例接受 IGRT 治疗的患者的平均喉和下咽剂量。分别为 41.2 Gy 和 22.8 Gy 的 IMRT 和 IGRT 技术的平均喉剂量（p<0.001）。IGRT 技术也显著降低了中咽和下咽肌肉的放射剂量。分别为 52 Gy 和 26 Gy 的 IMRT 和 IGRT 技术的平均咽剂量（p=0.0001）。即使存在颈部淋巴结，头颈部癌症的喉保护 IGRT 技术也可以在不牺牲靶区覆盖的情况下最大限度地减少喉和咽的放射剂量。
