通过 MudPIT 研究 MLL：鉴定将 MLL 融合蛋白和转录延伸因子聚集在一起的新复合物。
Taking MLL through the MudPIT: identification of novel complexes that bring together MLL-fusion proteins and transcription elongation factors.
机构信息
Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
出版信息
Mol Cell. 2010 Feb 26;37(4):449-50. doi: 10.1016/j.molcel.2010.02.005.
PMID:20188661
Abstract
Recently in Molecular Cell, Lin et al. (2010) showed that multiple MLL-fusion proteins implicated in mixed-lineage leukemia (MLL) associate with AFF4, ELLs, and the positive transcription elongation factor P-TEFb, providing evidence that the dysregulated gene expression in MLL patients is due to aberrant transcription elongation.
摘要
最近，在《分子细胞》杂志上，Lin 等人（2010）表明，多种涉及混合谱系白血病（MLL）的 MLL 融合蛋白与 AFF4、ELLs 和正向转录伸长因子 P-TEFb 相关，这为 MLL 患者中失调的基因表达是由于异常转录伸长提供了证据。
Zotero 插件