Department of Biochemistry and Molecular Genetics, Box 800733, University of Virginia, Charlottesville, VA 22908, USA.
Mol Cell. 2010 Feb 26;37(4):453-4. doi: 10.1016/j.molcel.2010.02.004.
Although IKK-related kinases are known to augment immune pathways, their importance to DNA-damage response has not been previously elucidated; in this issue of Molecular Cell, Renner et al. (2010) show that genotoxic stress requires SUMOylated IKKvarepsilon to regulate NF-kappaB transcription and cell survival.
虽然已知 IKK 相关激酶可以增强免疫途径，但它们对 DNA 损伤反应的重要性以前尚未阐明；在本期《分子细胞》中，Renner 等人（2010）表明，遗传毒性应激需要 SUMOylated IKKvarepsilon 来调节 NF-κB 转录和细胞存活。
