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基因 GRB 相关结合蛋白 2 多态性 rs2373115 与蒙古阿尔茨海默病患者的关联分析。

Association analysis between polymorphism rs2373115 of gene GRB-associated binding protein 2 and Mongolian Alzheimer patients.

机构信息

Graduate School, Peking Union Medical College, Beijing 100730, China.

出版信息

Neurosci Lett. 2010 Aug 9;480(1):4-6. doi: 10.1016/j.neulet.2010.02.047. Epub 2010 Feb 25.

Abstract

GRB-associated binding protein 2 (GAB2) may function as a risk factor of Alzheimer disease (AD) by affecting hyperphosphorylation of tau, causing neurofibrillary tangles. There had been genomewide analysis discovering polymorphism rs2373115 correlated with AD and in this study we performed an association analysis on this polymorphism in 107:100 Mongolian Alzheimer patients and controls in order to discover whether this correlation can be replicated in Chinese minority group. The results showed negative results, indicating GAB2 rs2373115 polymorphism was not a remarkable factor in developing Alzheimer disease among Mongolian.

摘要

GRB 相关衔接蛋白 2(GAB2)可能通过影响 tau 的过度磷酸化,导致神经原纤维缠结,从而成为阿尔茨海默病(AD)的风险因素。全基因组分析发现了与 AD 相关的多态性 rs2373115,本研究对 107 例蒙古裔 AD 患者和对照组进行了该多态性的关联分析,以发现这一相关性是否可以在汉族少数民族中得到复制。结果显示为阴性结果,表明 GAB2 rs2373115 多态性不是蒙古裔人群发生阿尔茨海默病的显著因素。

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