Laboratori de Neurofarmacologia, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, PRBB Barcelona, Spain.
Eur Neuropsychopharmacol. 2010 Jun;20(6):369-78. doi: 10.1016/j.euroneuro.2010.02.003. Epub 2010 Feb 26.
We have evaluated the effects of chronic nicotine administration and withdrawal in food intake and preference, metabolic parameters and anxiety-like behaviour in CB(1) knockout mice and wild-type littermates. Mutant mice showed lower levels of glucose, insulin and cholesterol after two weeks of high fat diet and reduced preference for saccharin solution when compared with wild-type mice. Nicotine reduced body weight and induced anxiogenic-like effects in wild-type, but not in CB(1) knockout mice. Our results suggest a modulatory role of the endocannabinoid system on the effects induced by nicotine on metabolic parameters and anxiety-like responses.
我们评估了慢性尼古丁给药和戒断对 CB(1) 敲除小鼠和野生型同窝仔鼠的食物摄入和偏好、代谢参数和焦虑样行为的影响。与野生型小鼠相比，突变小鼠在高脂饮食两周后血糖、胰岛素和胆固醇水平较低，对蔗糖溶液的偏好降低。与野生型小鼠相比，尼古丁降低了体重，并在野生型小鼠中引起焦虑样效应，但在 CB(1) 敲除小鼠中没有。我们的结果表明，内源性大麻素系统对尼古丁引起的代谢参数和焦虑样反应的影响具有调节作用。
