Aberdeen Pain Research Collaboration, Centre of Academic Primary Care, University of Aberdeen, UK.
Eur J Pain. 2010 Sep;14(8):860-3. doi: 10.1016/j.ejpain.2010.02.001. Epub 2010 Feb 26.
A previous study has reported that chronic pain is associated with a higher incidence of overall and site-specific cancer in subsequent years. The aim of this study was to confirm or refute these findings. In 1996, a cohort of 6940 individuals was recruited, and information on chronic pain, general health and socio-demographic details collected. Ten years later, a record linkage study was conducted between these data and the routinely collected national dataset for cancer registration. Hazard ratios for the incidence of all cancers and eight cancer-specific sites by chronic pain status were calculated. Eighty-four percent of individuals from the original cohort were linked. After excluding those with a known previous cancer diagnosis, all non-melanoma skin cancers and cancers which were not first occurrences, a total of 646 cancers had occurred in 607 people since the baseline study. The overall cancer incidence in the cohort was 10.4% over the 10 years. There were no significant associations between chronic pain and all cancer, or any of the eight cancer-specific sites, after adjustment for age and sex. There was a significant increased risk of developing lymphoma/leukaemia amongst those with all chronic pain and various causes of chronic pain on univariate analysis. After adjustment, these trends remained, although most of the associations were no longer significant. There were no significant differences between those with severe chronic pain compared to those with mild chronic pain. The findings suggest that those with chronic pain are not at a significantly increased risk of developing cancer.
先前的研究报告称，慢性疼痛与随后几年中整体和特定部位癌症的发病率较高有关。本研究旨在证实或反驳这些发现。1996 年，招募了一组 6940 人，并收集了有关慢性疼痛、一般健康和社会人口统计学细节的信息。10 年后，对这些数据与常规收集的癌症登记国家数据集进行了记录链接研究。根据慢性疼痛状况计算了所有癌症和 8 个特定癌症部位的发病率风险比。原始队列中 84%的人被链接。在排除已知患有先前癌症的人以及所有非黑色素瘤皮肤癌和非首次发生的癌症后，自基线研究以来，共有 607 人中有 646 人发生了 646 例癌症。该队列在 10 年内的总体癌症发病率为 10.4%。在调整年龄和性别后，慢性疼痛与所有癌症或任何 8 种特定癌症部位之间均无显著关联。在单变量分析中，所有慢性疼痛和各种原因的慢性疼痛患者中发生淋巴瘤/白血病的风险显著增加。调整后，这些趋势仍然存在，尽管大多数关联不再显著。严重慢性疼痛患者与轻度慢性疼痛患者之间没有差异。研究结果表明，慢性疼痛患者发生癌症的风险没有显著增加。
