Department of Otorhinolaryngology-Head and Neck Surgery, University of Brescia, Piazza Spedali Civili 1, 25123 Brescia, Italy.
Oral Oncol. 2010 Apr;46(4):307-10. doi: 10.1016/j.oraloncology.2010.01.020. Epub 2010 Feb 26.
Narrow band imaging (NBI) is an optical technique in which filtered light enhances superficial neoplasms based on their neoangiogenic pattern. The accuracy of NBI can be augmented by combining it with high definition television (HDTV). The aim of this study was to prospectively assess the diagnostic value of NBI in combination with HDTV in evaluation of oral (O) and oropharyngeal (OP) squamous cell carcinoma (SCC). Between April 2007 and December 2009, we analyzed 96 patients who were divided into 2 groups: Group A included 35 patients previously biopsied and diagnosed with OSCC or OPSCC and subjected to pre- and intraoperative HDTV white light (WL) and HDTV NBI endoscopy; Group B included 61 subjects already treated for OSCC or OPSCC and followed-up with HDTV WL and HDTV NBI. Fourteen of 35 (40%) patients in Group A showed adjunctive findings with NBI compared to standard WL. All of these findings were histologically confirmed. Twelve of 61 (20%) patients in Group B showed positive NBI findings, which were all confirmed by histology. The sensitivity, specificity, positive, negative predictive values, and accuracy for HDTV WL were 51%, 100%, 100%, 87%, and 68%, respectively, whilst for HDTV NBI were 96%, 100%, 100%, 93%, and 97%, respectively. Overall, 26 of 96 (27%) patients had a diagnostic advantage in applying NBI and HDTV: 6 patients received a diagnosis of recurrence and 1 of persistence after previous treatments; 5 showed a metachronous tumour; in 4 a synchronous tumour was diagnosed; 9 lesions were upstaged; in 1 patient previously diagnosed with an unknown primary by fine needle aspiration cytology on the neck, an anterior tonsillar pillar cancer was identified.
窄带成像（NBI）是一种光学技术，通过过滤光根据新生血管模式增强浅表肿瘤。将其与高清电视（HDTV）相结合可以提高 NBI 的准确性。本研究旨在前瞻性评估 NBI 结合 HDTV 在评估口腔（O）和口咽（OP）鳞状细胞癌（SCC）中的诊断价值。在 2007 年 4 月至 2009 年 12 月期间，我们分析了 96 例患者，将其分为 2 组：A 组包括 35 例先前活检和诊断为 OSCC 或 OPSCC 的患者，接受术前和术中 HDTV 白光（WL）和 HDTV NBI 内窥镜检查；B 组包括 61 例已接受 OSCC 或 OPSCC 治疗并随访 HDTV WL 和 HDTV NBI 的患者。A 组中有 14 例（40%）患者的 NBI 检查显示附加发现，而标准 WL 检查则无。所有这些发现均经组织学证实。B 组中有 12 例（20%）患者的 NBI 检查结果为阳性，均经组织学证实。HDTV WL 的灵敏度、特异性、阳性预测值、阴性预测值和准确性分别为 51%、100%、100%、87%和 68%，而 HDTV NBI 的分别为 96%、100%、100%、93%和 97%。总的来说，96 例患者中有 26 例（27%）在应用 NBI 和 HDTV 方面具有诊断优势：6 例患者在先前治疗后被诊断为复发和持续存在；5 例显示为同时性肿瘤；4 例诊断为同步性肿瘤；9 例病变升级；1 例患者先前在颈部通过细针抽吸细胞学检查诊断为不明原发灶，在咽前柱发现了扁桃体癌。
