全面分析腮腺和唾液腺癌：男性性别预后更差。
A comprehensive analysis of parotid and salivary gland cancer: worse outcomes for male gender.
机构信息
DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.
出版信息
J Surg Res. 2011 Nov;171(1):151-8. doi: 10.1016/j.jss.2009.11.721. Epub 2010 Feb 6.
BACKGROUND
To determine the effects of patient demographics, socioeconomic status (SES) and clinical variables on outcomes for patients with salivary and parotid gland tumors.
METHODS
Florida cancer registry and inpatient hospital data were queried for cancer of the salivary glands diagnosed between 1998-2002.
RESULTS
A total of 1573 patients were identified. Women were diagnosed at a younger age (median age (years): women 60.8 versus men 64.3, P=0.003). Men were more often diagnosed with high grade tumors (65.1% versus 41.9% for women, P<0.001) and advanced disease stage (>stage III: 60.2 versus 49.4%, P<0.001), but underwent surgical extirpation and received radiation at equal rates compared with women. Overall 5-year survival rates was superior in women (67.4% versus 55.6%, P=0.001). By multivariate analysis, adjusted for patient comorbidities, age over 65 (HR 3.43 P=0.008), advanced disease stage (HR 8.05 P<0.001), and high tumor grade (HR 2.33, P<0.001) were independent predictors of worse prognosis. Improved outcomes were observed for female gender (HR 0.68, P=0.011). Tumors located in the parotid gland (HR 0.631 P=0.003) and receiving both surgical extirpation and radiation were predictors of improved survival.
CONCLUSION
Salivary gland tumors carry a worse prognosis than tumors of the parotid. Male patients have worse outcomes.
背景
为了确定患者人口统计学、社会经济地位（SES）和临床变量对唾液腺和腮腺肿瘤患者结局的影响。
方法
从 1998 年至 2002 年期间，佛罗里达州癌症登记处和住院患者数据中查询了唾液腺癌的诊断情况。
结果
共确定了 1573 名患者。女性的诊断年龄更小（中位年龄（岁）：女性 60.8 岁，男性 64.3 岁，P=0.003）。男性更常被诊断为高级别肿瘤（女性为 65.1%，男性为 41.9%，P<0.001）和晚期疾病阶段（>III 期：女性为 60.2%，男性为 49.4%，P<0.001），但手术切除和放疗的比例与女性相同。总体 5 年生存率女性更高（67.4%对 55.6%，P=0.001）。通过多变量分析，调整患者合并症、年龄超过 65 岁（HR 3.43，P=0.008）、晚期疾病阶段（HR 8.05，P<0.001）和高级别肿瘤（HR 2.33，P<0.001）是预后不良的独立预测因素。女性性别（HR 0.68，P=0.011）是改善结局的一个预测因素。肿瘤位于腮腺（HR 0.631，P=0.003）和接受手术切除和放疗是改善生存的预测因素。
结论
与腮腺肿瘤相比，唾液腺肿瘤的预后更差。男性患者的预后更差。
Zotero 插件