Behzadi Mehrdad, Hajimohamadi Fatemeh, Alagha Afshar Etemadi, Abouzari Mehdi, Rashidi Armin
Amir-Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Int J Pediatr Otorhinolaryngol. 2010 May;74(5):486-8. doi: 10.1016/j.ijporl.2010.01.025. Epub 2010 Mar 1.
Instillation of lidocaine into the endotracheal tube cuff is a method with reported efficiency in promoting a smoother emergence from anesthesia with endotracheal intubation. However, whether or not this method is helpful in children and in surgeries with short duration has not been investigated previously.
176 ASA I-II children undergoing adenotonsillectomy were enrolled in this prospective, double-blind, randomized clinical trial. Patients were randomly allocated to two groups. Patients in the ECL group (n=88) were injected 2% lidocaine into their endotracheal tube cuff and received saline (1.5mg/kg) intravenously. The IVL group (n=88) received 1.5mg/kg of 2% lidocaine intravenously and saline into the endotracheal tube cuff. In both groups, intra-cuff injections were initiated immediately after insertion of the endotracheal tube and terminated before the cuff pressure reached 20 cmH(2)O. The parameters measured were: coughing (graded by a scale of 3 at the time of extubation), systolic and diastolic blood pressures and heart rate (from the time of extubation up to 5 min after extubation at 1-min intervals), and laryngospasm (defined as the presence of hoarseness or absence of airflow).
The groups were not different in sex, age, weight, height, body mass index, anesthesia duration, and baseline hemodynamic parameters. The grade of coughing was significantly higher in the ECL group. The incidence of laryngospasm and hemodynamic trends did not differ between the groups.
Our results indicate that intra-cuff lidocaine may not be beneficial in children and in surgeries with a short duration.
将利多卡因注入气管导管套囊是一种据报道能有效促进气管插管麻醉后苏醒更平稳的方法。然而,此前尚未研究该方法对儿童及短时长手术是否有帮助。
176例接受腺样体扁桃体切除术的美国麻醉医师协会(ASA)I-II级儿童纳入了这项前瞻性、双盲、随机临床试验。患者被随机分为两组。气管导管套囊利多卡因组(ECL组,n = 88)向气管导管套囊内注入2%利多卡因,并静脉注射生理盐水(1.5mg/kg)。静脉利多卡因组(IVL组,n = 88)静脉注射1.5mg/kg的2%利多卡因,并向气管导管套囊内注入生理盐水。两组均在气管导管插入后立即开始套囊内注射,并在套囊压力达到20 cmH₂O之前结束。测量的参数包括:咳嗽(拔管时按3级评分)、收缩压和舒张压以及心率(从拔管时起至拔管后5分钟,每隔1分钟测量一次),以及喉痉挛(定义为声音嘶哑或无气流)。
两组在性别、年龄、体重、身高、体重指数、麻醉时长和基线血流动力学参数方面无差异。ECL组的咳嗽分级明显更高。两组之间喉痉挛的发生率和血流动力学趋势没有差异。
我们的结果表明,套囊内注入利多卡因对儿童及短时长手术可能并无益处。