Martins Luciana M N, Camargos Paulo A M, Becker Helena M G, Becker Celso G, Guimarães Roberto E S
Department of Otorhinolaryngology, Medical School, Federal University of Minas, Gerais, Brazil.
Int J Pediatr Otorhinolaryngol. 2010 May;74(5):469-73. doi: 10.1016/j.ijporl.2010.01.021. Epub 2010 Mar 1.
To verify the prevalence of hearing loss in cystic fibrosis patients and whether the use of aminoglycosides affects hearing and also to analyze whether the distortion product otoacoustic emissions test is suitable to assess sensorineural hearing loss in cystic fibrosis.
In this descriptive study 120 cystic fibrosis patients aged five months to 18 years were assessed through questionnaires, audiometric tests and analysis of the distortion product otoacoustic emissions. Assessment of previous use of aminoglycosides was performed by collecting data in medical charts.
Audiometric tests show a 4-11% prevalence of sensorineural hearing loss. 89.2% of the patients succeeded in the otoacoustic emissions test, and 42% had used intravenous and/or inhaled aminoglycosides. There was no statistically significant (p=0.48) relation between the use of aminoglycosides and hearing loss.
Pure tone audiometry and analysis of the distortion product otoacoustic emissions revealed that there was a high prevalence of hearing loss, which makes cystic fibrosis patients a high-risk group which needs periodic assessment by an otorhinolaryngologist. Comparison of the groups with and without aminoglycosides use showed that there was no statistically significant difference among them in analyses, which suggests that the use of aminoglycosides is not the only causal factor for hearing loss in cystic fibrosis.
验证囊性纤维化患者听力损失的患病率，以及氨基糖苷类药物的使用是否会影响听力，并分析畸变产物耳声发射测试是否适用于评估囊性纤维化患者的感音神经性听力损失。
在这项描述性研究中，通过问卷调查、听力测试和畸变产物耳声发射分析，对120名年龄在5个月至18岁之间的囊性纤维化患者进行了评估。通过收集病历中的数据，对以前使用氨基糖苷类药物的情况进行了评估。
听力测试显示感音神经性听力损失的患病率为4%-11%。89.2%的患者耳声发射测试成功，42%的患者使用过静脉内和/或吸入性氨基糖苷类药物。氨基糖苷类药物的使用与听力损失之间没有统计学上的显著关系（p=0.48）。
纯音听力测定和畸变产物耳声发射分析显示，听力损失的患病率很高，这使得囊性纤维化患者成为一个高危群体，需要耳鼻喉科医生进行定期评估。使用和未使用氨基糖苷类药物的组间比较显示，在分析中它们之间没有统计学上的显著差异，这表明氨基糖苷类药物的使用不是囊性纤维化患者听力损失的唯一因果因素。
