Cheng Alan G, Johnston Patrick R, Luz Jennifer, Uluer Ahmet, Fligor Brian, Licameli Greg R, Kenna Margaret A, Jones Dwight T
Department of Otolaryngology and Communication Enhancement, Children's Hospital Boston, and Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USA.
Otolaryngol Head Neck Surg. 2009 Jul;141(1):86-90. doi: 10.1016/j.otohns.2009.03.020.
To determine the prevalence of sensorineural hearing loss (SNHL) in cystic fibrosis (CF) patients and its relationship to antibiotic use.
Case series with chart review.
Tertiary care pediatric hospital.
We reviewed the medical records of CF patients seen in our children's hospital between March 1994 and December 2007. Data collected included patient demographics, audiograms, tympanograms, genotype, and use of potentially ototoxic antibiotics.
Seven of 50 (14%) patients had SNHL. Three percent of patients who received <or=10 courses of intravenous aminoglycosides had SNHL versus 43 percent of those who received >10 courses (P<0.01). No patients who received five or fewer courses of nasal irrigation with aminoglycosides had SNHL versus 23 percent of those who received more than five courses (P<0.05). Nine percent of patients who received five or fewer courses of macrolides had SNHL versus 60 percent of those who received more than five courses (P=0.079).
CF patients receiving aminoglycosides are at high risk for developing SNHL.
确定囊性纤维化（CF）患者感音神经性听力损失（SNHL）的患病率及其与抗生素使用的关系。
病例系列并进行病历回顾。
三级儿科专科医院。
我们回顾了1994年3月至2007年12月期间在我院就诊的CF患者的病历。收集的数据包括患者人口统计学资料、听力图、鼓室图、基因型以及潜在耳毒性抗生素的使用情况。
50例患者中有7例（14%）患有SNHL。接受≤10个疗程静脉用氨基糖苷类抗生素治疗的患者中3%患有SNHL，而接受>10个疗程治疗的患者中这一比例为43%（P<0.01）。接受≤5个疗程氨基糖苷类抗生素鼻腔冲洗治疗的患者中无SNHL病例，而接受超过5个疗程治疗的患者中这一比例为23%（P<0.05）。接受≤5个疗程大环内酯类抗生素治疗的患者中9%患有SNHL，而接受超过5个疗程治疗的患者中这一比例为60%（P=0.079）。
接受氨基糖苷类抗生素治疗的CF患者发生SNHL的风险较高。
