School of Human Life Sciences, University of Tasmania, Launceston, Australia.
Int J Cardiol. 2011 Jun 16;149(3):330-4. doi: 10.1016/j.ijcard.2010.02.012. Epub 2010 Mar 1.
The Angiotensin Converting Enzyme (ACE) gene may influence the risk of heart disease and the response to various forms of exercise training may be at least partly dependent on the ACE genotype. We aimed to determine the effect of ACE genotype on the response to moderate intensity circuit resistance training in chronic heart failure (CHF) patients.
The relationship between ACE genotype and the response to 11weeks of resistance exercise training was determined in 37 CHF patients (New York Heart Association Functional Class=2.3±0.5; left ventricular ejection fraction 28±7%; age 64±12years; 32:5 male:female) who were randomised to either resistance exercise (n=19) or inactive control group (n=18). Outcome measures included V˙O(2peak), peak power output and muscle strength and endurance. ACE genotype was determined using standard methods.
At baseline, patients who were homozygous for the I allele had higher V˙O(2peak) (p=0.02) and peak power (p=0.003) compared to patients who were homozygous for the D allele. Patients with the D allele, who were randomised to resistance training, compared to non-exercising controls, had greater peak power increases (ID p<0.001; DD p<0.001) when compared with patients homozygous for the I allele, who did not improve. No significant genotype-dependent changes were observed in V˙O(2peak), muscle strength, muscle endurance or lactate threshold.
ACE genotype may have a role in exercise tolerance in CHF and could also influence the effectiveness of resistance training in this condition.
血管紧张素转换酶（ACE）基因可能会影响患心脏病的风险，而对各种形式的运动训练的反应至少部分取决于 ACE 基因型。我们旨在确定 ACE 基因型对慢性心力衰竭（CHF）患者进行中等强度循环抗阻训练反应的影响。
在 37 名 CHF 患者（纽约心脏协会功能分级=2.3±0.5；左心室射血分数 28±7%；年龄 64±12 岁；32:5 男:女）中，确定 ACE 基因型与抗阻运动训练 11 周的反应之间的关系，这些患者被随机分为抗阻运动组（n=19）或非运动对照组（n=18）。结果测量包括 V˙O(2peak)、最大功率输出和肌肉力量及耐力。ACE 基因型采用标准方法确定。
在基线时，与 D 等位基因纯合子相比，I 等位基因纯合子患者的 V˙O(2peak)（p=0.02）和最大功率（p=0.003）更高。在随机接受抗阻训练的 D 等位基因患者中，与非运动对照组相比，I 等位基因纯合子患者的最大功率增加更大（ID p<0.001；DD p<0.001），而后者则没有改善。在 V˙O(2peak)、肌肉力量、肌肉耐力或乳酸阈方面，未观察到与基因型相关的显著变化。
ACE 基因型可能在 CHF 的运动耐量中起作用，并且也可能影响这种情况下的抗阻训练的有效性。
