University of Burgundy, Department of Physiology, UPRES EA4183 Lipids and Cell Signalling, Faculty of Life Sciences, Dijon, France.
Prostaglandins Leukot Essent Fatty Acids. 2010 Apr-Jun;82(4-6):179-87. doi: 10.1016/j.plefa.2010.02.023. Epub 2010 Mar 1.
n-3 polyunsaturated fatty acids (PUFA) have been shown to modulate immune responses. These agents, being considered as adjuvant immunosuppressants, have been used in the treatment of various inflammatory and autoimmune diseases. However, the molecular mechanisms of action of n-3 PUFA-induced immunosuppressive effects are not well-understood. Since exogenous n-3 PUFA, under in vitro and in vivo conditions, are efficiently incorporated into T-cell plasma membranes, a number of recent studies have demonstrated that these agents may modulate T-cell signalling. In this review, the interactions of n-3 PUFA with the second messenger cascade initiated during early and late events of T-cell activation are discussed. We particularly focus on how these fatty acids can modulate the production of diacylglycerol and the activation of protein kinase C, mitogen activated protein kinase, calcium signalling and translocation of transcriptional factors, implicated in the regulation of gene transcription in T-cells.
n-3 多不饱和脂肪酸（PUFA）已被证明可调节免疫反应。这些被认为是佐剂免疫抑制剂的药物已被用于治疗各种炎症和自身免疫性疾病。然而，n-3 PUFA 诱导免疫抑制作用的分子机制尚不清楚。由于外源性 n-3 PUFA 在体外和体内条件下可有效地掺入 T 细胞质膜中，因此最近的许多研究表明，这些药物可能调节 T 细胞信号转导。在这篇综述中，讨论了 n-3 PUFA 与 T 细胞活化早期和晚期事件中启动的第二信使级联之间的相互作用。我们特别关注这些脂肪酸如何调节二酰基甘油的产生以及蛋白激酶 C、有丝分裂原激活蛋白激酶、钙信号和转录因子转位的激活，这些都与 T 细胞中基因转录的调节有关。
