SprB 是沙门氏菌致病性岛 1（SPI1）和 SPI4 之间的分子连接。
SprB is the molecular link between Salmonella pathogenicity island 1 (SPI1) and SPI4.
机构信息
Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, IL 61801, USA.
出版信息
J Bacteriol. 2010 May;192(9):2459-62. doi: 10.1128/JB.00047-10. Epub 2010 Feb 26.
Abstract
Salmonella pathogenicity island 1 (SPI1) and SPI4 have previously been shown to be jointly regulated. We report that SPI1 and SPI4 gene expression is linked through a transcriptional activator, SprB, encoded within SPI1 and regulated by HilA. SprB directly activates SPI4 gene expression and weakly represses SPI1 gene expression through HilD.
摘要
先前已经表明，沙门氏菌致病岛 1（SPI1）和 SPI4 共同受到调节。我们报告称，SPI1 和 SPI4 的基因表达通过 SPI1 内编码的转录激活因子 SprB 连接在一起，SprB 受 HilA 调节。SprB 通过 HilD 直接激活 SPI4 基因表达，并微弱抑制 SPI1 基因表达。
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