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足踝部软组织肉瘤的保肢治疗

Limb salvage for soft-tissue sarcomas of the foot and ankle.

作者信息

Cribb G L, Loo S C S, Dickinson I

机构信息

Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry SY10 7AG, UK.

出版信息

J Bone Joint Surg Br. 2010 Mar;92(3):424-9. doi: 10.1302/0301-620X.92B3.22331.

Abstract

We evaluated the oncological and functional outcome of 27 patients who had limb salvage for a soft-tissue sarcoma of the foot or ankle between 1992 and 2007, with a mean follow-up of 7.5 years (1.05 to 16.2). There were 12 men and 15 women, with a mean age at presentation of 47 years (12 to 84). Referrals came from other hospitals for 16 patients who had previous biopsy or unplanned excision, and 11 presented de novo. There were 18 tumours located in the foot and nine around the ankle. Synovial sarcoma was the most frequent histological diagnosis. Excision was performed in all cases, with 16 patients requiring plastic surgical reconstruction with 13 free and three local flaps. Adjuvant treatment was undertaken in 20 patients, 18 with radiotherapy and two by chemotherapy. Limb salvage was successful in 26 of the 27 patients. There have been two local recurrences and two mesenchymal metastases. Four patients have died of their sarcoma and two of other causes. Function was evaluated with the Toronto Extremity Salvage Score and a mean overall score of 89.40 (52.1 to 100) was obtained. A questionnaire revealed that all surviving patients are able to wear normal shoes and none require a walking aid. Limb salvage can achieve good oncological and functional results with additional treatment.

摘要

我们评估了1992年至2007年间因足部或踝关节软组织肉瘤而接受保肢治疗的27例患者的肿瘤学及功能预后情况,平均随访时间为7.5年(1.05至16.2年)。其中男性12例,女性15例,就诊时的平均年龄为47岁(12至84岁)。16例患者是从其他医院转诊而来,之前曾接受过活检或意外切除,11例为初诊患者。18个肿瘤位于足部,9个位于踝关节周围。滑膜肉瘤是最常见的组织学诊断类型。所有病例均进行了切除手术,16例患者需要整形外科重建,其中13例采用游离皮瓣,3例采用局部皮瓣。20例患者接受了辅助治疗,18例接受放疗,2例接受化疗。27例患者中有26例保肢成功。出现了2例局部复发和2例间叶组织转移。4例患者死于肉瘤,2例死于其他原因。采用多伦多肢体 salvage 评分对功能进行评估,平均总评分为89.40(52.1至100)。一份调查问卷显示,所有存活患者都能够穿正常鞋子,且均无需助行器。通过额外治疗,保肢可取得良好的肿瘤学及功能效果。

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