Takada Junichi, Iba Kousuke, Yamashita Toshihiko, Yoshizaki Takashi
Kitago Orthopaedic Clinic/Department of Orthopaedic Surgery, Sapporo Medical University.
Clin Calcium. 2010 Mar;20(3):355-63.
The effects of treatment with raloxifene on bone quality (proximal femur geometry) are evaluated by hip structure analysis. Raloxifene shows the significant improvement of the index of resistance to bending forces (section modulus) in Japanese patients with postmenopausal osteoporosis. Raloxifene decreased the endocortical bone resorption without affecting the periosteal bone formation. These mechanism induced the increasing the cortical thickness, cross section area, and bone strength. A similar trend was seen in the bisphosphonates. On the other hand, teriparatide increase bone mineral density and bone strength in femoral neck and intertrochanter, but did not show significant changes in femoral shaft.
通过髋部结构分析评估雷洛昔芬治疗对骨质量（股骨近端几何结构）的影响。在日本绝经后骨质疏松症患者中，雷洛昔芬显示出抗弯力指数（截面模量）有显著改善。雷洛昔芬减少了皮质内骨吸收，而不影响骨膜骨形成。这些机制导致皮质厚度、横截面积和骨强度增加。双膦酸盐类药物也观察到类似趋势。另一方面，特立帕肽可增加股骨颈和转子间的骨矿物质密度和骨强度，但股骨干未显示出显著变化。
