Department of Internal Medicine III, Osaka Medical College, Takatsuki, Japan.
Circ J. 2010 Apr;74(4):741-8. doi: 10.1253/circj.cj-09-0564. Epub 2010 Feb 27.
S100A8/A9 complex (S100A8/A9) is expressed in activated human neutrophils and macrophages. Enhanced expression of S100A8/A9 in atherosclerotic plaque of patients with unstable angina pectoris (UAP) has been demonstrated, but its profile in acute myocardial infarction (AMI) has not been clarified.
Serum S100A8/A9 levels were serially measured in patients with AMI (n=55) and UAP (n=16) during the acute period. The expression of S100A8/A9 was examined immunohistochemically in the infarcted myocardium of 7 autopsied patients with AMI. Serum S100A8/A9 levels on the 1st day were 1,118+/-115 (SE) ng/ml in AMI patients as compared with 787+/-147 ng/ml in UAP patients. On days 3-5, serum S100A8/A9 levels in AMI patients reached a peak value and were significantly higher than the values in UAP patients (1,690+/-144 ng/ml vs 844+/-100 ng/ml; P<0.0001). In AMI patients, peak S100A8/A9 levels positively correlated with peak white blood cell and neutrophil counts, and peak creatine kinase-MB and peak C-reactive protein levels. Double immunostaining revealed that S100A8/A9 was specifically expressed in neutrophils and macrophages infiltrating the infarcted myocardium.
S100A8/A9 is implicated in the pathophysiology of AMI and may be an additional biomarker of the local inflammatory response following AMI.
S100A8/A9 复合物(S100A8/A9)在激活的人中性粒细胞和巨噬细胞中表达。已经证明,不稳定型心绞痛(UAP)患者的动脉粥样硬化斑块中 S100A8/A9 的表达增强,但在急性心肌梗死(AMI)中的情况尚不清楚。
在急性期间,连续测量了 AMI(n=55)和 UAP(n=16)患者的血清 S100A8/A9 水平。在 7 例 AMI 尸检患者的梗死心肌中,通过免疫组织化学方法检查了 S100A8/A9 的表达。AMI 患者第 1 天的血清 S100A8/A9 水平为 1118+/-115(SE)ng/ml,而 UAP 患者为 787+/-147 ng/ml。在第 3-5 天,AMI 患者的血清 S100A8/A9 水平达到峰值,明显高于 UAP 患者(1690+/-144 ng/ml vs 844+/-100 ng/ml;P<0.0001)。在 AMI 患者中,峰值 S100A8/A9 水平与峰值白细胞和中性粒细胞计数、峰值肌酸激酶-MB 和峰值 C 反应蛋白水平呈正相关。双免疫染色显示 S100A8/A9 特异性表达于浸润梗死心肌的中性粒细胞和巨噬细胞。
S100A8/A9 参与 AMI 的病理生理学,可能是 AMI 后局部炎症反应的附加生物标志物。