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S100a8/A9蛋白：心血管疾病炎症的关键调节因子。

S100a8/A9 proteins: critical regulators of inflammation in cardiovascular diseases.

作者信息

Sun Yu, Xu Han, Gao Weihan, Deng Jinlan, Song Xiayinan, Li Jie, Liu Xijian

机构信息

College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.

Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.

出版信息

Front Cardiovasc Med. 2024 Aug 8;11:1394137. doi: 10.3389/fcvm.2024.1394137. eCollection 2024.

DOI:10.3389/fcvm.2024.1394137
PMID:39175627
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11338807/
Abstract

Neutrophil hyperexpression is recognized as a key prognostic factor for inflammation and is closely related to the emergence of a wide range of cardiovascular disorders. In recent years, S100 calcium binding protein A8/A9 (S100A8/A9) derived from neutrophils has attracted increasing attention as an important warning protein for cardiovascular disease. This article evaluates the utility of S100A8/A9 protein as a biomarker and therapeutic target for diagnosing cardiovascular diseases, considering its structural features, fundamental biological properties, and its multifaceted influence on cardiovascular conditions including atherosclerosis, myocardial infarction, myocardial ischemia/reperfusion injury, and heart failure.

摘要

中性粒细胞过度表达被认为是炎症的关键预后因素，并且与多种心血管疾病的发生密切相关。近年来，源自中性粒细胞的S100钙结合蛋白A8/A9（S100A8/A9）作为心血管疾病的重要预警蛋白受到越来越多的关注。本文考虑到S100A8/A9蛋白的结构特征、基本生物学特性及其对包括动脉粥样硬化、心肌梗死、心肌缺血/再灌注损伤和心力衰竭在内的心血管疾病的多方面影响，评估了其作为诊断心血管疾病的生物标志物和治疗靶点的效用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/473e/11338807/7284af161d28/fcvm-11-1394137-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/473e/11338807/37f967fa816c/fcvm-11-1394137-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/473e/11338807/7284af161d28/fcvm-11-1394137-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/473e/11338807/37f967fa816c/fcvm-11-1394137-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/473e/11338807/7284af161d28/fcvm-11-1394137-g002.jpg

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Nat Commun. 2024 Mar 27;15(1):2701. doi: 10.1038/s41467-024-46973-7.
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