肺结核患者的肠道屏障功能和利福平、异烟肼及吡嗪酰胺的血清浓度。
Intestinal barrier function and serum concentrations of rifampin, isoniazid and pyrazinamide in patients with pulmonary tuberculosis.
机构信息
Clinical Research Unit & Institute of Biomedicine, Center for Global Health, Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, Fortaleza.
出版信息
Braz J Infect Dis. 2009 Jun;13(3):210-7. doi: 10.1590/s1413-86702009000300011.
Intestinal barrier function and serum concentrations of rifampin, isoniazid and pyrazinamide were studied in healthy controls and patients with active pulmonary tuberculosis. A case-control study of 29 controls and 30 cases attending at the Health Center, July, 2004 to December, 2005 was conducted. The body mass index was significantly reduced in cases compared to controls (p < 0.001). The intestinal paracellular transport of lactulose was significantly (p = 0.019) reduced in cases compared to controls. The transcellular transport of mannitol and the lactulose:mannitol ratio were not significantly (p = 0.0698) reduced in cases compared to controls. Low serum concentrations of rifampin, isoniazid and pyrazinamide were observed in 81% (48/59), 92% (54/59) and 28% (12/59), respectively, in all individuals. The results demonstrated a marked decrease on intestinal paracellular transport in patients with active pulmonary tuberculosis and reduced serum concentrations of rifampin and isoniazid in both groups.
研究了健康对照者和活动性肺结核患者的肠道屏障功能以及利福平、异烟肼和吡嗪酰胺的血清浓度。2004 年 7 月至 2005 年 12 月，在健康中心对 29 名对照者和 30 例病例进行了病例对照研究。与对照组相比，病例组的体重指数显著降低（p<0.001）。与对照组相比，病例组的乳果糖经肠道细胞旁转运明显减少（p=0.019）。与对照组相比，甘露糖醇的经肠道细胞转运和乳果糖：甘露糖醇比值在病例组中没有显著减少（p=0.0698）。在所有个体中，分别观察到利福平、异烟肼和吡嗪酰胺的血清浓度低，分别为 81%（48/59）、92%（54/59）和 28%（12/59）。结果表明，活动性肺结核患者的肠道细胞旁转运明显减少，两组患者的利福平、异烟肼血清浓度均降低。
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