多模态治疗复发性小唾液腺癌患者。

Multimodal treatment of patients with minor salivary gland cancer in the case of recurrent disease.

机构信息

Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria.

出版信息

Head Neck. 2010 Sep;32(9):1167-72. doi: 10.1002/hed.21312.

DOI:10.1002/hed.21312

PMID:20191625

Abstract

BACKGROUND

Our aim in this study was to identify prognostic factors and the optimal therapeutic management in patients with minor salivary gland carcinomas.

METHODS

Overall and disease-free survival and overall survival after recurrence in patients with adenoidcystic carcinoma (n = 25), mucoepidermoid carcinoma (n = 8), adenocarcinoma (n = 5), carcinoma ex pleomorphic adenoma (n = 4), and others (n = 5) were correlated to clinical data.

RESULTS

Overall survival correlated to treatment modality (p = .039) and T classification (p = .003), whereas prolonged disease-free interval correlated to treatment (p < .001) and T classification (p = .009). Overall survival after recurrence correlated to treatment of recurrence (p = .006) and initial T classification (p = .02). Multivariate analysis showed that overall survival after recurrence correlated to treatment of recurrence (p = .019) and initial T classification (p = 0.019). T classification was a prognostic factor for overall survival (p = .002) and disease-free interval (p = .002).

CONCLUSIONS

The initial tumor classification is a clinical predictor for patients' overall and disease-free survival and overall survival after recurrence. Multimodal treatment significantly improves patients' overall survival.

摘要

背景

本研究旨在确定小唾液腺癌患者的预后因素和最佳治疗方法。

方法

对 25 例腺样囊性癌、8 例黏液表皮样癌、5 例腺癌、4 例癌在多形性腺瘤中的病例、5 例其他类型的患者的总生存率、无病生存率和复发后总生存率与临床资料进行相关性分析。

结果

总生存率与治疗方式（p =.039）和 T 分类（p =.003）相关，而无病间隔时间与治疗（p <.001）和 T 分类（p =.009）相关。复发后的总生存率与复发的治疗（p =.006）和初始 T 分类（p =.02）相关。多因素分析显示，复发后总生存率与复发的治疗（p =.019）和初始 T 分类（p = 0.019）相关。T 分类是总生存率（p =.002）和无病间隔时间（p =.002）的预后因素。